DOI : https://doi.org/10.1016/j.bea.2025.100172 (논문링크)
Abstract
Stem Cells (SCs) have become potentially instrumental in addressing many human diseases such as cancer, diabetes, age-related diseases and tissue defects. The unique ability of SCs to multiply indefinitely and differentiate into various cell types makes them invaluable in regenerative medicine and treatment. Regenerative medicine is an advancing field that focuses on restoring tissue and organ function in individuals with severe injuries and chronic illnesses. Pluripotent cells, capable of adopting roles from any of the three germ layers, exhibit exceptional versatility and are promising for a wide range of medical conditions. They also offer a solution to limitations posed by animal models in understanding specific disorders. Recent breakthroughs have shown that combining SCs with cutting-edge technologies like 3D bioprinting and 3D culture systems can revolutionize tissue engineering and organ regeneration. 3D bioprinting allows precise construction of complex tissue structures, bringing us closer to recreating functional organs for transplantation. Moreover, the integration of SCs with gene editing techniques presents unprecedented opportunities for precise genetic modification, correcting disease-causing mutations and opening avenues for personalized therapies. In addition, SCs play an important role in drug discovery and testing, serving as valuable models for studying disease mechanisms and screening potential therapeutic biomolecules. This paper provides a comprehensive exploration of SCs, transcription factors, diverse therapeutic applications of these cells as well as their role in the fields of tissue engineering, 3D bioprinting, 3D culture systems, gene editing, disease modeling, and drug discovery and testing.
Summary
본 논문은 줄기세포의 유형, 치료 적용 사례, 제조 기술, 윤리적 이슈, 그리고 임상 적용의 한계와 미래 전략을 종합적으로 분석한 최신 리뷰 논문입니다.
주요 줄기세포 유형 및 특성
유형특징치료적 강점 > 특히 MSCs의 면역조절 기능은 염증성 질환 치료에서 중요한 경쟁력
| MSCs (중간엽줄기세포) | 면역조절 능력 | 염증·자가면역·퇴행성 질환 |
| ESCs (배아줄기세포) | 높은 분화능 | 다양한 조직 재생 |
| iPSCs (유도만능줄기세포) | 환자 유래 제작 가능 | 맞춤형 치료, 면역거부 감소 |
줄기세포 치료는 재생의학의 핵심 축으로서, 향후 다음 방향으로 진화할 전망입니다.
세포치료 + 유전자편집 융합
면역치료와의 통합 플랫폼화
자동화 기반 GMP 대량생산
AI 기반 정밀 세포 설계
장기 대체 수준의 조직 재생
기술·제조·규제 체계가 성숙할 경우, 줄기세포 치료는 기존 치료가 어려웠던 난치성 질환 영역을 근본적으로 변화시킬 잠재력을 보유하고 있습니다.
DOI : https://doi.org/10.1016/j.bea.2025.100172 (논문링크)
Abstract
Stem Cells (SCs) have become potentially instrumental in addressing many human diseases such as cancer, diabetes, age-related diseases and tissue defects. The unique ability of SCs to multiply indefinitely and differentiate into various cell types makes them invaluable in regenerative medicine and treatment. Regenerative medicine is an advancing field that focuses on restoring tissue and organ function in individuals with severe injuries and chronic illnesses. Pluripotent cells, capable of adopting roles from any of the three germ layers, exhibit exceptional versatility and are promising for a wide range of medical conditions. They also offer a solution to limitations posed by animal models in understanding specific disorders. Recent breakthroughs have shown that combining SCs with cutting-edge technologies like 3D bioprinting and 3D culture systems can revolutionize tissue engineering and organ regeneration. 3D bioprinting allows precise construction of complex tissue structures, bringing us closer to recreating functional organs for transplantation. Moreover, the integration of SCs with gene editing techniques presents unprecedented opportunities for precise genetic modification, correcting disease-causing mutations and opening avenues for personalized therapies. In addition, SCs play an important role in drug discovery and testing, serving as valuable models for studying disease mechanisms and screening potential therapeutic biomolecules. This paper provides a comprehensive exploration of SCs, transcription factors, diverse therapeutic applications of these cells as well as their role in the fields of tissue engineering, 3D bioprinting, 3D culture systems, gene editing, disease modeling, and drug discovery and testing.
Summary
본 논문은 줄기세포의 유형, 치료 적용 사례, 제조 기술, 윤리적 이슈, 그리고 임상 적용의 한계와 미래 전략을 종합적으로 분석한 최신 리뷰 논문입니다.
주요 줄기세포 유형 및 특성
유형특징치료적 강점 > 특히 MSCs의 면역조절 기능은 염증성 질환 치료에서 중요한 경쟁력
줄기세포 치료는 재생의학의 핵심 축으로서, 향후 다음 방향으로 진화할 전망입니다.
세포치료 + 유전자편집 융합
면역치료와의 통합 플랫폼화
자동화 기반 GMP 대량생산
AI 기반 정밀 세포 설계
장기 대체 수준의 조직 재생
기술·제조·규제 체계가 성숙할 경우, 줄기세포 치료는 기존 치료가 어려웠던 난치성 질환 영역을 근본적으로 변화시킬 잠재력을 보유하고 있습니다.