DOI : 10.21203/rs.3.rs-3875687/v1 (논문링크)
Abstract
Background: The aim of this investigation was to identify and compare changes in the quality of life among patients with knee osteoarthritis treated with injections of bone marrow aspirate concentrate,platelet-rich plasma, and hyaluronic acid.
Methods: The study employed a single-center prospective clinical trial with three study arms, and data were collected through repeated measurements using the self-reported SF-36 scale. To analyze the data's nature, linear mixed models (LMMs) were utilized to determine which of the three injection types was most effective in enhancing the quality of life. LMMs extend the principles of linear regression to accommodate correlated observations and analyze data collected at various time points.
Results: A total of 175 patients underwent treatment and screening over a 12-month period. Patients who received bone marrow aspirate concentrate (BMAC) exhibited greater score improvement compared to those receiving hyaluronic acid (HA) or platelet-rich plasma (PRP). This effect was most prominent in role limitations due to physical health and physical functioning. Additionally, results indicated score improvements for patients receiving PRP compared to those receiving HA, though not all findings achieved statistical significance.
Conclusions: Our study demonstrated that patients treated with BMAC experienced a more significant enhancement in quality of life compared to those receiving HA and PRP. The most substantial improvement was observed in factors related to physical movement, indicating the effectiveness of BMAC in restoring patients' physical functioning. Study limitations include recruitment from a single center and a relatively small dataset, particularly for those undergoing HA and PRP therapy.
Summary
BMAC 치료군
PRP 치료군
Hyaluronic Acid 치료군
PRP vs BMAC vs HA 비교 임상 연구
무릎 골관절염 환자를 대상으로 PRP, BMAC, Hyaluronic Acid 치료 효과 비교
세 치료 모두 삶의 질 개선 효과 확인
BMAC 치료군에서 신체 기능 및 활동성 개선이 가장 크게 나타남
PRP는 통증 감소 및 기능 개선에서 긍정적 결과
> Orthobiologics 치료가 단순 통증 조절을 넘어 기능 회복 치료로 확장 가능함을 시사
PRP와 BMAC은 현재 정형외과 재생치료 분야에서 가장 활발히 연구되는 biologics 치료법입니다. 특히 BMAC은 줄기세포 기반 regenerative therapy로서 기능 회복 및 조직 재생 측면에서 잠재력이 제시되고 있으며, PRP는 염증 조절과 통증 완화 측면에서 보조적 치료 전략으로 활용 가능성이 보고되고 있습니다. 향후 연구에서는 치료 표준화, 장기 임상 결과, 병합 치료 전략에 대한 추가적인 임상 데이터 확보가 중요할 것으로 판단됩니다.
DOI : 10.21203/rs.3.rs-3875687/v1 (논문링크)
Abstract
Background: The aim of this investigation was to identify and compare changes in the quality of life among patients with knee osteoarthritis treated with injections of bone marrow aspirate concentrate,platelet-rich plasma, and hyaluronic acid.
Methods: The study employed a single-center prospective clinical trial with three study arms, and data were collected through repeated measurements using the self-reported SF-36 scale. To analyze the data's nature, linear mixed models (LMMs) were utilized to determine which of the three injection types was most effective in enhancing the quality of life. LMMs extend the principles of linear regression to accommodate correlated observations and analyze data collected at various time points.
Results: A total of 175 patients underwent treatment and screening over a 12-month period. Patients who received bone marrow aspirate concentrate (BMAC) exhibited greater score improvement compared to those receiving hyaluronic acid (HA) or platelet-rich plasma (PRP). This effect was most prominent in role limitations due to physical health and physical functioning. Additionally, results indicated score improvements for patients receiving PRP compared to those receiving HA, though not all findings achieved statistical significance.
Conclusions: Our study demonstrated that patients treated with BMAC experienced a more significant enhancement in quality of life compared to those receiving HA and PRP. The most substantial improvement was observed in factors related to physical movement, indicating the effectiveness of BMAC in restoring patients' physical functioning. Study limitations include recruitment from a single center and a relatively small dataset, particularly for those undergoing HA and PRP therapy.
Summary
BMAC 치료군
신체 기능(physical functioning)
활동 능력
전반적 건강 인식 에서 가장 큰 개선 효과
PRP 치료군
통증 감소 및 기능 개선에서 긍정적 효과 확인
HA 대비 일부 삶의 질 지표에서 더 우수한 결과
Hyaluronic Acid 치료군
통증 완화 및 기능 개선 효과는 확인되었으나
전반적인 삶의 질 개선 정도는 PRP 및 BMAC 대비 상대적으로 제한적
PRP vs BMAC vs HA 비교 임상 연구
무릎 골관절염 환자를 대상으로 PRP, BMAC, Hyaluronic Acid 치료 효과 비교
세 치료 모두 삶의 질 개선 효과 확인
BMAC 치료군에서 신체 기능 및 활동성 개선이 가장 크게 나타남
PRP는 통증 감소 및 기능 개선에서 긍정적 결과
> Orthobiologics 치료가 단순 통증 조절을 넘어 기능 회복 치료로 확장 가능함을 시사
PRP와 BMAC은 현재 정형외과 재생치료 분야에서 가장 활발히 연구되는 biologics 치료법입니다. 특히 BMAC은 줄기세포 기반 regenerative therapy로서 기능 회복 및 조직 재생 측면에서 잠재력이 제시되고 있으며, PRP는 염증 조절과 통증 완화 측면에서 보조적 치료 전략으로 활용 가능성이 보고되고 있습니다. 향후 연구에서는 치료 표준화, 장기 임상 결과, 병합 치료 전략에 대한 추가적인 임상 데이터 확보가 중요할 것으로 판단됩니다.