Background: Diabetes is one of the metabolic diseases characterized by hyperglycemia, with many complications. Diabetic foot ulcer (DFU) is a significant complication of diabetes. Various therapy procedures have been recently described for DFU improvement. Methods: Using PubMed, Scopus, Science Direct, and Google Scholar to discover the therapeutic effects of bee products, this review study was conducted in 2018-2019 by searching PubMed, Scopus, Science Direct, and Google Scholar databases. Results: Cell therapies with various cell candidates such as mesenchymal stem cells (MSCs) are increasingly introduced into routine medical care to manage skin wounds. The applying of these cells for tissue regeneration was initially based on the capability of MSCs to differentiate into specialized cells within the injured tissue. Paracrine signaling and differentiation mechanisms have both been contributed to improving tissue repair by MCSs. However, the role of MSCs differentiation is less due to the poor survival of these cells at the site of injury. Conclusion: At the same time, paracrine signaling or their secretome is the primary mechanism of MSCs that stimulate neovascularization and re-epithelialization and mobilization of inhabitant stem cells. In this review study, we discuss the role of MSCs and their secretome that can improve the use of this new approach in treating ulcers and DFU.
Summary
MSC 기반 치료는 당뇨병성 족부 궤양에 있어 유망한 전략입니다. 이 치료의 핵심은 MSC가 직접 새로운 조직이 되는 것보다, 주변분비 신호를 통해 상처 부위에 혈관 생성을 유도하고, 피부 세포의 증식을 촉진하며, 염증을 조절하는 등 국소 환경을 개선하는 것에 있습니다. 즉, MSC는 직접 집을 짓는 '일꾼'이라기보다는, 치유 과정을 지휘하고 촉진하는 '감독관'의 역할을 수행한다고 볼 수 있습니다.
DOI : 10.52547/wjps.11.1.12 원문
Abstract
Background: Diabetes is one of the metabolic diseases characterized by hyperglycemia, with many complications. Diabetic foot ulcer (DFU) is a significant complication of diabetes. Various therapy procedures have been recently described for DFU improvement.
Methods: Using PubMed, Scopus, Science Direct, and Google Scholar to discover the therapeutic effects of bee products, this review study was conducted in 2018-2019 by searching PubMed, Scopus, Science Direct, and Google Scholar databases.
Results: Cell therapies with various cell candidates such as mesenchymal stem cells (MSCs) are increasingly introduced into routine medical care to manage skin wounds. The applying of these cells for tissue regeneration was initially based on the capability of MSCs to differentiate into specialized cells within the injured tissue. Paracrine signaling and differentiation mechanisms have both been contributed to improving tissue repair by MCSs. However, the role of MSCs differentiation is less due to the poor survival of these cells at the site of injury.
Conclusion: At the same time, paracrine signaling or their secretome is the primary mechanism of MSCs that stimulate neovascularization and re-epithelialization and mobilization of inhabitant stem cells. In this review study, we discuss the role of MSCs and their secretome that can improve the use of this new approach in treating ulcers and DFU.
Summary
MSC 기반 치료는 당뇨병성 족부 궤양에 있어 유망한 전략입니다. 이 치료의 핵심은 MSC가 직접 새로운 조직이 되는 것보다, 주변분비 신호를 통해 상처 부위에 혈관 생성을 유도하고, 피부 세포의 증식을 촉진하며, 염증을 조절하는 등 국소 환경을 개선하는 것에 있습니다. 즉, MSC는 직접 집을 짓는 '일꾼'이라기보다는, 치유 과정을 지휘하고 촉진하는 '감독관'의 역할을 수행한다고 볼 수 있습니다.